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Curcumin, the active ingredient in the spice turmeric, may help treat upset stomach and arthritis; it also has shown potential in the prevention and treatment of cancer, although research is still in the preliminary stages. While the amount of curcumin you consume in your diet through the use of turmeric in curries and other dishes is considered safe, taking curcumin supplements may cause some adverse effects. You should first discuss curcumin’s safety with your doctor.

Side Effects

Turmeric side effects tend to be mild and include dizziness, diarrhea, nausea, upset stomach, gas and indigestion. Consuming large amounts of turmeric for extended periods may increase your risk for ulcers and skin rashes. Some people also experience allergic reactions to turmeric, which can include swelling, hives and difficulty breathing.

Risks During Pregnancy

The large doses of curcumin in supplements may bring on menstruation and cause miscarriages in pregnant women, according to Drugs.com. These supplements also aren’t recommended for women who are breastfeeding, since they haven’t been verified to be safe. But the amount of turmeric and curcumin in foods is safe during pregnancy, notes the University of Maryland Medical Center.

Kidney and Gallbladder Problems

You shouldn’t take curcumin if you have a blocked bile duct or other gallbladder problems, because it can make these issues worse, notes MedlinePlus. Curcumin may also increase your risk for developing kidney stones if you’re prone to them, notes the American Cancer Society, because it appears to change how your body processes oxalate, one of the components of some types of kidney stones.

Medication Interactions

Curcumin can interact with some medications, including blood-clotting medications, increasing your risk for excessive bruising and bleeding. It may interact with antacids to cause an increase in the amount of stomach acid formed, and with blood sugar-lowering medications, causing blood sugar levels that are too low. You also risk adverse effects if you combine curcumin with nonsteroidal pain relievers, such as ibuprofen, or medications that suppress your immune function.